امرأة عمرها ٦٠ سنة عندها ارتفاع ضغط، بدأت أملوديبين ١٠ ملغ قبل شهر. ضغطها الآن ١٣٢/٨٠. تشتكي تورماً في الكاحلين يزيد آخر النهار، بدون ضيق نفس، أو زيادة وزن كبيرة، أو خراخر في الرئتين. ما التفسير الأنسب؟

A 60-year-old woman with hypertension started amlodipine 10 mg a month ago; BP is now 132/80. She reports ankle swelling worse at the end of the day, without breathlessness, significant weight gain or lung crackles. What is the most fitting explanation?

1. A known side effect of amlodipine from vasodilation
2. Bilateral deep vein thrombosis
3. Drug-induced kidney failure
4. Acute heart failure needing emergency care

Answer: A) A known side effect of amlodipine from vasodilation. Ankle oedema is a common side effect of dihydropyridine calcium channel blockers from arteriolar dilation. The prescriber is told so the dose or drug can be adjusted, after checking there are no heart-failure signs.